Parkinson’s Disease Quality of Life: Disease Severity Outweighs Pain Impact

Neila Raisa, Yulianda Maziya, Annisa Rahma, Novita Titis Harbiyanti, Shahdevi Nandar Kurniawan

Abstract


Introduction: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, progressively affecting both motor and non-motor systems in patients. In addition to the commonly recognized motor symptoms such as tremor, rigidity, and bradykinesia, non-motor symptoms such as chronic pain are often underdiagnosed. Pain in Parkinson's patients can manifest in various forms, including musculoskeletal pain, neuropathic pain, and dystonic pain. While pain is not a primary symptom defining Parkinson's, its impact on patients' quality of life is profound, contributing to reduced mobility, sleep disturbances, increased risk of falls, and poor mental health, including depression and anxiety. This study aimed to explore the relationship between the severity of Parkinson's disease, pain levels, and quality of life in Parkinson's patients. Method: A cross-sectional observational study was conducted at the Neurology Clinic of RSUD Dr. Saiful Anwar in East Java from October 2023 to March 2024, using purposive sampling techniques. We assessed Parkinson's severity (Hoehn & Yahr scale), pain levels (Numeric Rating Scale), and quality of life (Parkinson's Disease Questionnaire-39 (PDQ-39) Indonesian Version). Result: The study found that PDQ-39 INA scores were significantly associated with Parkinson's disease severity (n = 11, p = 0.012), indicating a significant impact of disease severity on quality of life. However, no significant relationship was found between PDQ-39 scores and pain levels (p = 0.117). Pearson correlation analysis showed no significant relationship between Parkinson's severity scale and pain level (r = 0.461, p = 0.154). Specifically, Parkinson's severity significantly affected PDQ-39 scores (p = 0.001), while pain levels did not have a significant effect (p = 0.399). Conclusion: This study reveals that while pain is a critical issue, it is the severity of Parkinson's disease that has a more substantial impact on patients' quality of life.

Keywords


Parkinson's Disease Severity; Pain Levels; Quality of Life; Parkinson's Disease

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References


Andrew, A. S., Anderson, F. L., Lee, S. L., et al. (2021). Lifestyle factors and Parkinson’s disease risk in a rural New England case-control study. Parkinson’s Disease, 2021, 1–7. https://doi.org/10.1155/2021/5546817

Anindyta, M. A., & Sutarni, S. (2020). Perbandingan kualitas hidup pasien Parkinson subtipe tremor dominant dan postural instability gait disorder. Callosum Neurology Journal, 3(1), 35–42.

Buhmann, C., Kassubek, J., & Jost, W. H. (2020). Management of pain in Parkinson’s disease. Journal of Parkinson's Disease, 10(S1), S37–S48. https://doi.org/10.3233/JPD-202072

Camacho-Conde, J. A., & Campos-Arillo, V. M. (2020). The phenomenology of pain in Parkinson’s disease. Korean Journal of Pain, 33(1), 90–96. https://doi.org/10.3344/kjp.2020.33.1.90

Choi, S.-M., Kim, B. C., Jung, H.-J., et al. (2017). Impact of pain and pain subtypes on the quality of life of patients with Parkinson’s disease. Journal of Clinical Neuroscience, 45, 105–109. https://doi.org/10.1016/j.jocn.2017.06.004

Emamzadeh, F. N., & Surguchov, A. (2018). Parkinson’s disease: Biomarkers, treatment, and risk factors. Frontiers in Neuroscience, 12, 612. https://doi.org/10.3389/fnins.2018.00612

Haeriyoko, W. A., Samatra, D. P., GS, S. Y. T., et al. (2018). Profil gangguan tidur penderita Parkinson di rumah sakit rujukan di Kota Denpasar tahun 2018. Callosum Neurology Journal, 3(1), 1–10.

Heidiyana, M., Surbakti, K. P., & Hutagalung, H. S. (2023). The association between degree of severity and number of medications with quality of life in Parkinson’s disease patients. Journal of Society Medicine, 2(3), 103–112. https://doi.org/10.31228/josmed-2023-021

Hoang, D. T., Xing, F., Nguyen, T. D., et al. (2023). Pain is common in early onset Parkinson’s disease and pain severity is associated with age and worsening of motor and non-motor symptoms. Journal of Neurological Sciences, 455, 122784. https://doi.org/10.1016/j.jns.2023.122784

Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: onset, progression, and mortality. Neurology, 17(5), 427–442. https://doi.org/10.1212/WNL.17.5.427

Jin, Y., Mao, Z., Ling, Z., et al. (2017). Altered emotional recognition and expression in patients with Parkinson’s disease. Neuropsychiatric Disease and Treatment, 13, 2891–2902. https://doi.org/10.2147/NDT.S147508

Kilinc, B., Cetisli-Korkmaz, N., Bir, L. S., et al. (2023). The quality of life in individuals with Parkinson’s disease: Is it related to functionality and tremor severity? A cross-sectional study. Physiotherapy Theory and Practice, 1–10. https://doi.org/10.1080/09593985.2023.2214349

Marino, B. L. B., de Souza, L. R., Sousa, K. P. A., et al. (2020). Parkinson’s disease: A review from pathophysiology to treatment. Mini-Reviews in Medicinal Chemistry, 20(8), 754–767. https://doi.org/10.2174/1389557520666191127145941

Masaki, M., Takeuchi, M., Kasahara, M., et al. (2023). Association of activities of daily living, mobility and balance ability, and symptoms of Parkinson’s disease with the masses and amounts of intramuscular non-contractile tissue of the trunk and lower extremity muscles in patients with Parkinson’s disease. Journal of Medical Ultrasonics, 50(4), 551–560. https://doi.org/10.1007/s10396-023-01219-1

Mehanna, R., Smilowska, K., Fleisher, J., et al. (2022). Age cutoff for early‐onset Parkinson’s disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson’s Disease. Movement Disorders Clinical Practice, 9(6), 869–878. https://doi.org/10.1002/mdc3.13477

Morales-Briceño, H., Mohammad, S. S., Post, B., et al. (2020). Clinical and neuroimaging phenotypes of genetic parkinsonism from infancy to adolescence. Brain, 143(3), 751–770. https://doi.org/10.1093/brain/awaa032

Neff, C., Wang, M. C., & Martel, H. (2018). Using the PDQ-39 in routine care for Parkinson’s disease. Parkinsonism & Related Disorders, 53, 105–107. https://doi.org/10.1016/j.parkreldis.2018.05.009

Oktariza, Y., Amalia, L., Sobaryati, & Kurniawati, M. Y. (2019). Evaluasi kualitas hidup pasien Parkinson berdasarkan terapi berbasis Levodopa. Jurnal Farmasi Klinik Indonesia, 8(4), 246–255. https://doi.org/10.15416/ijcp.2019.8.4.246

Pagano, G., Ferrara, N., Brooks, D. J., et al. (2016). Age at onset and Parkinson disease phenotype. Neurology, 86(14), 1400–1407. https://doi.org/10.1212/WNL.0000000000002461

Pereira, M. G., Carvalho, C., Costa, E. C. V., et al. (2021). Quality of life in chronic pain patients: Illness‐ and wellness‐focused coping as moderators. Psych Journal, 10(2), 283–294. https://doi.org/10.1002/pchj.440

Politis, M., Wu, K., Molloy, S., Bain, P., Chaudhuri, K. R., & Piccini, P. (2020). Parkinson's disease symptoms: The patient’s perspective. Movement Disorders, 35(1), 120-128. https://doi.org/10.1002/mds.23862

Post, B., van den Heuvel, L., van Prooije, T., et al. (2020). Young onset Parkinson’s disease: A modern and tailored approach. Journal of Parkinson's Disease, 10(S1), S29–S36. https://doi.org/10.3233/JPD-202072

Schönenberg, A., & Prell, T. (2022). Measuring quality of life with the Parkinson’s Disease Questionnaire-39 in people with cognitive impairment. PLoS ONE, 17(3), e0266140. https://doi.org/10.1371/journal.pone.0266140

Schrag, A., Hovris, A., Morley, D., et al. (2017). Young‐ versus older‐onset Parkinson’s disease: Impact of disease and psychosocial consequences. Movement Disorders, 18(11), 1250–1256. https://doi.org/10.1002/mds.10578

Setiarini, R. (2018). Profil pasien Parkinson di poliklinik saraf RSUP Dr. Sardjito. Fakultas Kedokteran Universitas Gadjah Mada. [Unpublished manuscript].

Tambun, O., Marisdina, S., & Bahar, E. (2021). Faktor-faktor yang mempengaruhi kualitas hidup penderita penyakit Parkinson dengan menggunakan. Unpublished manuscript.

Valkovic, P., Minar, M., Singliarova, H., Harsany, J., Hanakova, M., & Martinkova, J. (2015). Pain in Parkinson’s disease: A cross-sectional study of its prevalence, types, and relationship to depression and quality of life. PloS one, 10(8), e0136541. https://doi.org/10.1371/journal.pone.0136541

Young Blood, M. R., Ferro, M. M., Munhoz, R. P., et al. (2016). Classification and characteristics of pain associated with Parkinson’s disease. Parkinson’s Disease, 2016, 1–8. https://doi.org/10.1155/2016/6067132

Zhao, N., Yang, Y., Zhang, L., et al. (2021). Quality of life in Parkinson’s disease: A systematic review and meta‐analysis of comparative studies. CNS Neuroscience & Therapeutics, 27(3), 270–279. https://doi.org/10.1111/cns.13531




DOI: https://doi.org/10.32807/jkp.v18i2.1657

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